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Four-Sided Optical Quartz Flow Cell Fluorescence Cuvettes for Continuous Fluorescence Analysis -TOQUARTZ®
Features of Four-Sided Optical Quartz Flow Cell Fluorescence Cuvettes
The TOQUARTZ® Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette represents the pinnacle of optical precision for continuous flow analysis applications. These flow cells are engineered for researchers and equipment manufacturers requiring superior optical transmission, chemical resistance, and thermal stability.
Optical Properties
- Four-sided transparency enabling multi-angle light detection
- Exceptional UV-VIS-NIR light transmission (190-2500nm wavelength range)
- No absorption peaks within working spectrum
- Optically polished surfaces with flatness of λ/10
Material Characteristics
- Ultra-high purity quartz (≥99.98%, up to 99.995% SiO₂)
- Superior chemical resistance to acids, bases, organic solvents
- Low thermal expansion coefficient (5.5×10⁻⁷/°C)
Precision Engineering
- Dimensional tolerance of ±0.1mm
- Uniform wall thickness for consistent optical path
- Bubble-free and streak-free optical windows
- SiO2 Purity ≥99.98%, up to 99.995%
- Chemical Resistance to Harsh Reagents
- Customization Services Available
Technical Specifications & Dimensions of Four-Sided Optical Quartz Flow Cell Fluorescence Cuvettes
Technical Specifications
| Parameter | Specification |
| 1. Physical Properties | |
| Material | High-purity fused quartz |
| Purity | ≥99.98%, up to 99.995% SiO₂ |
| Density | 2.2 g/cm³ |
| Hardness | 5.5-6.5 Mohs |
| Tensile Strength | 48-54 MPa |
| Thermal Expansion | 5.5×10-7/℃ |
| 2. Chemical Properties | |
| Chemical Composition | SiO₂ (≥99.98%) |
| Impurity Levels | Na, K, Li, Fe, Al < 10 ppm |
| Chemical Resistance | Excellent to acids, bases, solvents |
| pH Resistance | 1-14 |
| Water Absorption | Negligible (<0.01%) |
| Gas Permeability | Extremely low |
| 3. Optical Properties | |
| Transmission Range | 190-2500nm |
| UV Cutoff | <190nm |
| Transmission at 220nm | 80% |
| Transmission at 260nm | 90% |
| Refractive Index | 1.458 at 546nm |
| Surface Quality | 80/50 scratch/dig |
| Flatness | λ/10 |
Size Chart
| Model | Description | Windows | Outline Dimension |
| AT-BSM-6023 | Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette | 10 | 40x40x83mm |
TOQUARTZ® Critical Challenges in Analytical Applications with Four-Sided Optical Quartz Flow Cell Fluorescence Cuvettes
Real-Time Fluorescence Monitoring in Microfluidic Drug Screening Systems
Key Advantages
-
Multi-angle excitation window design
Enables 4-directional fluorescence excitation/emission, increasing signal capture by 22% in microfluidic assays. -
Dead volume minimized to <1.2μL
Optimized internal geometry reduces reagent waste and improves assay repeatability in nanoliter-scale screening. -
Integrated flow channel with 0.5mm ID
Supports stable laminar flow at 5–50 μL/min, ideal for high-throughput drug screening platforms.
TOQUARTZ® solution
A U.S.-based pharmaceutical lab using a two-sided cuvette reported 18% signal loss and 12% false negatives in nanoliter assays due to limited excitation angles and dead volume. After switching to TOQUARTZ® Four-Sided Flow Cells, signal intensity improved by 22%, and assay repeatability increased by 30%, enabling reliable screening of 1,200 compounds/day.
Inline Fluorescence Detection in Bioreactor Fermentation Monitoring
Key Advantages
-
SIP-compatible up to 121°C for 60 min
Validated for 50+ steam-in-place cycles without optical degradation or structural failure. -
Dual-axis fluorescence detection support
Four-sided transparency allows orthogonal excitation/emission for NADH/FAD monitoring with <2% signal drift. -
Anti-fouling polished inner surface (Ra < 0.02μm)
Reduces biofilm adhesion by 65%, extending cleaning intervals in continuous fermentation.
TOQUARTZ® solution
A Korean biopharma facility experienced weekly signal drift >10% due to fouling in standard flow cells, requiring CIP every 3 days. TOQUARTZ® flow cells maintained <2% drift over 21 days of continuous fermentation, reducing cleaning frequency by 66% and increasing batch yield by 12%.
Fluorescence-Based Water Quality Analysis in Environmental Monitoring Stations
Key Advantages
-
Four-sided UV-grade quartz for 3-wavelength detection
Supports simultaneous excitation at 254nm, 280nm, and 365nm for PAH and DOM analysis. -
Thermal stability from -20°C to 120°C
Ensures consistent performance in outdoor stations with seasonal temperature fluctuations. -
Customizable flow ports for inline analyzers
Compatible with peristaltic pumps and autosamplers, enabling 24/7 unattended operation.
TOQUARTZ® solution
A German environmental agency reported 15% data loss in winter due to cuvette fogging and UV degradation. TOQUARTZ® flow cells maintained >90% UV transmission after 6 months of field use, reducing recalibration frequency by 40% and improving pollutant detection accuracy in low-light conditions.
TOQUARTZ® Customization Options for Four-Sided Optical Quartz Flow Cell Fluorescence Cuvettes
Application-Oriented Dimensional Customization
Instead of offering generic size options, TOQUARTZ® focuses on application-driven dimensional customization.
-
System Matching
Dimensions tailored to fit client-specific instruments. -
Optical Alignment
Ensures consistent path length and light transmission. -
Drawing Interpretation
Converts sketches or CAD into manufacturable designs. -
Use-Case Focused
Designed around actual detection or flow scenarios. -
Tolerance Control
Precision machining based on functional requirements.
Specialized Inlet/Outlet Configurations
We support a wide range of inlet/outlet customization options to ensure seamless integration with your fluidic systems, whether for lab-scale testing or embedded instrumentation.
-
Port Positioning
Custom inlet/outlet placement for system-specific alignment. -
Connection Interface
Compatible with Luer, threaded, or barbed fittings. -
Flow Directionality
Supports vertical or horizontal sample flow orientation. -
Multi-Port Design
Enables dual-channel or recirculation flow configurations. -
Sealing Compatibility
Designed for O-ring, gasket, or adhesive sealing.
Custom Development Process
TOQUARTZ® custom development process is designed to eliminate ambiguity, reduce iteration cycles, and ensure that your specifications are fully understood and implemented from the start.
-
Requirement Clarification
Translate functional needs into technical design parameters. -
Drawing Validation
Review and refine client-provided CAD or sketches. -
Feasibility Assessment
Evaluate manufacturability based on quartz processing limits. -
Optical Alignment Check
Ensure path length and window clarity meet detection needs. -
Interface Matching
Align cuvette geometry with instrument connection standards.
Usage and Care Guidelines
Handling and Installation
- Always handle cuvettes with powder-free gloves to prevent fingerprints and contamination
- When connecting tubing, avoid over-tightening fittings to prevent stress on the quartz
- Ensure inlet and outlet ports are properly aligned with your system's flow direction
- For horizontal mounting, provide adequate support to prevent stress on connection points
Cleaning Procedures
- Flush with appropriate solvent immediately after use to prevent sample residue
- For biological samples, rinse with enzyme cleaner followed by deionized water
- For persistent contamination, soak in 10% nitric acid solution for 30 minutes (avoid HF)
- For optical surfaces, use lens-grade microfiber cloth with isopropyl alcohol
Storage Recommendations
- Store in original protective case when not in use
- Keep inlet/outlet ports capped to prevent dust contamination
- Store in dry environment away from chemicals
- Avoid temperature extremes during storage
Lifetime Optimization
- Implement regular preventive maintenance schedule
- When using with particulate samples, consider pre-filtration
- Avoid rapid temperature changes that may cause thermal shock
- For UV applications, monitor cumulative exposure time
Need a custom Four-Sided Optical Quartz Flow Cell solution?
Why Partner with TOQUARTZ
Direct Factory Advantage
As a direct manufacturer, we can cut out the numerous intermediate links.
Engineering Expertise
Technical team guides clients from material selection to design optimization, translating specs into deliverables.
Flexible Manufacturing
Handling standard & custom orders via small-batch expertise and prototyping rigor to meet urgent deadlines.
Quality
Assurance
Pre-shipment 3-step validation:
1. dimensional accuracy,
2. material purity ,
3. performance thresholds
Global Supply Chain
Reliable global logistics to industrial hubs (DE/US/JP/KR priority) with trackable milestones.
Releted Products
As a specialized manufacturer with direct factory capabilities, TOQUARTZ provides both standard and custom quartz solutions with engineering support throughout the specification and implementation process.
FAQ
Q: What makes the Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette suitable for multi-angle fluorescence detection?
A: The Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette features four optically polished transparent surfaces. This allows excitation and emission light to pass through multiple angles without distortion. It enhances signal collection efficiency in fluorescence spectroscopy. This design is especially beneficial in systems using orthogonal or dual-wavelength detection.
Q: How does the flow-through design of the Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette improve real-time analysis?
A: The flow-through structure enables continuous sample movement during fluorescence measurement. This eliminates the need for manual sample replacement and reduces contamination risk. It supports real-time monitoring in microfluidic and inline systems. The Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette is ideal for dynamic assays.
Q: How does the Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette reduce signal loss in fluorescence detection?
A: Its four-sided transparency allows more excitation light to reach the sample and more emitted light to be collected. This reduces signal attenuation caused by limited optical access. The optically polished surfaces minimize scattering and distortion. As a result, fluorescence signal intensity is significantly improved.
Q: What are the advantages of using the Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette in environmental fluorescence monitoring?
A: Its four-sided design allows multi-wavelength excitation for detecting various pollutants. The flow-through structure supports continuous water sampling in field stations. It resists chemical corrosion from acidic or alkaline water sources. This ensures long-term stability in harsh environmental conditions.
Q: What makes the Four-Sided Optical Quartz Flow Cell Fluorescence Cuvette suitable for high-throughput fluorescence screening?
A: It supports automated sample flow and multi-angle detection, reducing manual handling. The design minimizes dead volume and improves signal consistency across replicates. It integrates easily with robotic liquid handlers and optical readers. This makes it ideal for pharmaceutical and biotech screening platforms.
Contact our engineering team for technical consultation and pricing. We’ll help you select the optimal specifications for your application requirements.
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